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Drug Updates
- Fostair 100/6 inhalation solution
- Epanutin capsules 25, 50 and 100mg
- Eprex 2000, 4000 and 10000 IU/ml solution for injection in pre-filled syringe
- FemSeven Conti
- Epanutin 300mg hard capsules
- Bedranol 80mg SR Capsules
- Bedranol 160mg SR Capsules
- Betim 10mg Tablets
- Carbo-Dome Cream
- Bisoprolol 2.5mg/5mg/10mg film coated tablet
- Phenergan Injection
- Rivotril 0.5 mg and 2 mgTablets
- Rivotril Ampoules
- RELPAX 20mg and 40mg Film-Coated Tablets
- Witch Doctor ® 81.5%w/w Gel
- Levetiracetam Actavis 1,000 mg film-coated tablets
- Levetiracetam Actavis 250 mg film-coated tablets
- Levetiracetam Actavis 500 mg film-coated tablets
- Levetiracetam Actavis 750 mg film-coated tablets
- Lidocaine Hydrochloride Injection BP 1% w/v plastic ampoules
- Lidocaine Hydrochloride Injection BP 2.0% w/v
- Omeprazole 10mg Capsules
- Omeprazole 20mg Capsules
- Panadol Extra Advance 500 mg/65 mg Tablets
- Allopurinol Tablets BP 300mg
- Allopurinol Tablets BP 100mg
- Anadin Ultra Double Strength 400mg Capsules/Anadin LiquiFast 400mg Capsules
- Calcipotriol Scalp Solution
- Bupivacaine Hydrochloride Injection BP 0.5% w/v.
- Lescol (fluvastatin* sodium) 20 mg and 40 mg capsules
- Meropenem 1 g Powder for Solution for Injection or Infusion
- VALTREX Tablets 250mg
- Vesicare 5mg & 10mg film-coated tablets
- Zomig 5mg Nasal Spray
- Water for Injections
- Tizanidine 2mg Tablets
- NovoRapid 100 U/ml in a vial, NovoRapid Penfill 100 U/ml, NovoRapid FlexPen 100 U/ml, NovoRapid FlexTouch 100 U/ml
- Orfadin 10 mg hard capsules
- Orfadin 2 mg hard capsules
- Natecal D3 Chewable Tablets
ADHD
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Adderall® XR prescribing information, USA. 2006.External Source Document
American Psychiatric Association. Attention-deficit and disruptive behavior disorders. Attention-deficit/hyperactivity disorder. In: Diagnostic and statistical manual of mental disorders. 2000, American Psychiatric Association. 85–103.External Source Document
Banaschewski T, Coghill D, Santosh P, Zuddas A, Asherson P, Buitelaar J, et al. Long-acting medications for the hyperkinetic disorders: A systematic review and European treatment guideline. Eur Child Adolesc Psychiatry 2006 May 5 [Epub ahead of print].External Source Document
Barkley R. International consensus statement on ADHD. Clin Child Family Psychol Rev 2002; 5: 89–111.External Source Document
Biederman J, Faraone SV. Attention-deficit hyperactivity disorder. Lancet 2005; 366: 237–48.External Source Document
Biederman J, Faraone SV. The Massachusetts General Hospital studies of gender influences on attention-deficit/hyperactivity disorder in youth and relatives. Psychiatr Clin North Am 2004; 27: 225–32.External Source Document
Biederman J, Kwon A, Aleardi M, Chouinard VA, Marino T, Cole H, et al. Absence of gender effects on attention deficit hyperactivity disorder: findings in nonreferred subjects. Am J Psychiatry 2005; 162: 1083–9.External Source Document
Biederman J, Mick E, Faraone SV. Age-dependent decline of symptoms of attention deficit hyperactivity disorder: impact of remission definition and symptom type. Am J Psychiatry 2000; 157: 816–8.External Source Document
Brown RT, Freeman WS, Perrin JM, Stein MT, Amler RW, Feldman HM, et al. Prevalence and assessment of attention-deficit/hyperactivity disorder in primary care settings. Pediatrics 2001; 107: E43.External Source Document
Clinical practice guideline: Diagnosis and evaluation of the child with attention-deficit/hyperactivity disorder. American Academy of Pediatrics. Pediatrics 2000; 105: 1158–70.External Source Document
Cohen P, Cohen J, Kasen S, Velez CN, Hartmark C, Johnson J, et al. An epidemiological study of disorders in late childhood and adolescence–I. Age- and gender-specific prevalence. J Child Psychol Psychiatry 1993; 34: 851–67.External Source Document Concerta® SPC, UK. 2006.External Source Document
Cunningham CE, Barkley RA. The interactions of normal and hyperactive children with their mothers in free play and structured tasks. Child Dev 1979; 50: 217–24.External Source Document
Cyr M, Brown CS. Current drug therapy recommendations for the treatment of attention deficit hyperactivity disorder. Drugs 1998; 56: 215–23.External Source Document
Datamonitor, Stakeholder insight: ADHD. Prescriber attention still held by short acting stimulant drugs. DMHC2008. 2004.External Source Document
Dexedrine tablets SPC, UK. 2005.External Source Document
Dextrostat tablets, prescribing information, USA. 2003.External Source Document
Dougherty DD, Bonab AA, Spencer TJ, Rauch SL, Madras BK, Fischman AJ. Dopamine transporter density in patients with attention deficit hyperactivity disorder. Lancet 1999; 354: 2132–3.External Source Document
Dulcan M. Practice parameters for the assessment and treatment of children, adolescents, and adults with attention-deficit/hyperactivity disorder. American Academy of Child and Adolescent Psychiatry. J Am Acad Child Adolesc Psychiatry 1997; 36: 85S–121S.External Source Document
Equasym™XL SPC, UK. 2006.External Source Document
Erickson JD, Schafer MK-H, Bonner TI, Eiden LE, Weihe E. Distinct pharmacological properties and distribution in neurons and endocrine cells of two isoforms of the human esicular monoamine transporter. Proc Natl Acad Sci USA 1996; 93: 5166–71.External Source Document
Escobar R, Soutullo CA, Hervas A, Gastaminza X, Polavieja P, Gilaberte I. Worse quality of life for children with newly diagnosed attention-deficit/hyperactivity disorder, compared with asthmatic and healthy children. Pediatrics 2005; 116: e364–9.External Source Document
Faraone SV, Biederman J. Neurobiology of attention-deficit hyperactivity disorder. Biol Psychiatry 1998; 44: 951-8.External Source Document
Fleckenstein AE, Gibb JW, Hanson GR. Differential effects of stimulants on monoaminergic transporters: Pharmacological consequences and implications for neurotoxicity. Eur J Pharmacol 2000; 406: 1–13.External Source Document
Garland M, Kirkpatrick P. Atomoxetine hydrochloride. Nat Rev Drug Discov 2004; 3: 385–6.External Source Document
Hill JC, Schoener EP. Age-dependent decline of attention deficit hyperactivity disorder. Am J Psychiatry 1996; 153: 1143–6.External Source Document
International statistical classification of diseases and related health problems, 10th Revision, version for 2006. 2006 Accessed October 2006.External Source Document
Jones SR, Joseph JD, Barak LS, Caron MG, Wightman RM. Dopamine neuronal transport kinetics and effects of amphetamine. J Neurochem 1999; 73: 2406–14.External Source Document
King S, Griffin S, Hodges Z, Weatherly, H, Asseburg C, Richardson G, et al. Methylphenidate, dexamfetamine and atomoxetine for the treatment of attention deficit hyperactivity disorder in children (commercial in confidence information removed): Centre for Reviews and Dissemination, Centre for Health Economics, University of York; December 2004.External Source Document
Klassen AF, Miller A, Fine S. Health-related quality of life in children and adolescents who have a diagnosis of attention-deficit/hyperactivity disorder.External Source Document
Kratochvil CJ, Vaughan BS, Harrington MJ, Burke WJ. Atomoxetine: A selective noradrenaline reuptake inhibitor for the treatment of attention-deficit/hyperactivity disorder. Expert Opin Pharmacother 2003; 4: 1165–74.External Source Document
Kuczenski R, Segal DS. Effects of methylphenidate on extracellular dopamine, serotonin, and norepinephrine: Comparison with amphetamine. J Neurochem 1997; 68: 2032–37.External Source Document
Levy F, Hay DA, Bennett KS, McStephen M. Gender differences in ADHD subtype comorbidity. J Am Acad Child Adolesc Psychiatry 2005; 44: 368–76.External Source Document
Liu F, Muniz R, Minami H, Silva RR. Review and comparison of the long acting methylphenidate preparations. Psychiatr Q 2005; 76: 259–69.External Source Document
Mannuzza S, Klein RG. Long-term prognosis in attention-deficit/hyperactivity disorder. Child Adolesc Psychiatr Clin N Am 2000; 9: 711–26.External Source Document
Markowitz JS, Straughn AB, Patrick KS. Advances in the pharmacotherapy of attention-deficit-hyperactivity disorder: Focus on methylphenidate formulations. Pharmacotherapy 2003; 23: 1281–99.External Source Document
Matza LS, Rentz AM, Secnik K, Swensen AR, Revicki DA, Michelson D, et al. The link between health-related quality of life and clinical symptoms among children with attention-deficit hyperactivity disorder. J Dev Behav Pediatr 2004; 25: 166–74.External Source Document
McGough JJ, Pataki CS, Suddath R. Dexmethylphenidate extended-release capsules for attention deficit hyperactivity disorder. Expert Rev Neurother 2005; 5: 437–41.External Source Document
Medikinet® retard SPC, Germany. 2005.External Source Document
MTA Cooperative Group. A 14-month randomized clinical trial of treatment strategies for attention-deficit/hyperactivity disorder. Arch Gen Psychiatry 1999; 56: 1073–86.External Source Document
National Institutes of Health Consensus Development Conference Statement: Diagnosis and treatment of attention-deficit/hyperactivity disorder (ADHD). J Am Acad Child Adolesc Psychiatry 2000; 39: 182–93.External Source Document
NICE. NICE technology appraisal guidance No 13. Guidance on the use of methylphenidate (Ritalin, Equasym) for attention deficit/hyperactivity disorder (ADHD) in childhood. 2000. 1–13.External Source Document
Nolan EE, Gadow KD, Sprafkin J. Stimulant medication withdrawal during long-term therapy in children with comorbid attention-deficit hyperactivity disorder and chronic multiple tic disorder. Pediatrics 1999; 103: 730-7.
Patrick KS, Markowitz JS. Pharmacology of methylphenidate, amphetamine enantiomers and pemoline in attention-deficit hyperactivity disorder. Hum Psychopharmacol 1997; 12: 527–46.
Polanczyk G, Silva de Lima M, Horta B, Biederman J, Rohde L. ADHD prevalence around the world: what are the real sources of variability in estimates? A systematic review and meta-regression analysis. In: 52nd Annual Meeting of the American Academy of Child and Adolescent Psychiatry (AACAP). 2005.Ritalin®LA™ PI. 2004.
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Rowland AS, Umbach DM, Catoe KE, Stallone L, Long S, Rabiner D, et al. Studying the epidemiology of attention-deficit hyperactivity disorder: screening method and pilot results. Can J Psychiatry 2001; 46: 931–40.
Selikowitz M. ADHD the facts. 2004. Oxford University Press.External Source Document
SIGN (Scottish Intercollegiate Guidelines Network). Attention deficit and hyperkinetic disorders in children and young people. A national clinical guideline. Volume 52. Edinburgh June 2001.External Source Document
Solanto MV. The neuroscience of stimulant drug action in ADHD. In: Stimulant Drugs and ADHD Basic and Clinical Neuroscience. 2001. 355–79.Spencer T, Biederman J, Wilens T, Prince J, Hatch M, Jones J, et al. Effectiveness and tolerability of tomoxetine in adults with attention deficit hyperactivity disorder. Am J Psychiatry 1998; 155: 693–5.External Source Document
Strattera (atomoxetine) SPC, UK. 2005.External Source Document
Suzuki O, Hattori H, Asano M, Oya M, Katsuma Y. Inhibition of monoamine oxidase by d-methamphetamine. Biochem Pharmacol 1980; 29: 2070–73.External Source Document
Taylor E, Döpfner M, Sergeant J, Asherson P, Banaschewski T, Buitelaar J, et al. European clinical guidelines for hyperkinetic disorder – first upgrade. Eur Child Adolesc Psychiatry 2004; 13 (Suppl 1): I7–I30.External Source Document
Taylor E, Döpfner M, Sergeant J, Asherson P, Banaschewski T, Rothenberger A, et al. European clinical guidelines for hyperkinetic disorder - first upgrade. Eur Child Adolesc Psychiatry 2004; 13: I7–I30.External Source Document
Volkow ND, Wang G, Fowler JS, Logan J, Gerasimov M, Maynard L, et al. Therapeutic doses of oral methylphenidate significantly increase extracellular dopamine in the human brain. J Neurosci 2001; 21: RC121.External Source Document
Weiner JM, Ed. 1997, Washington, DC, American Academy of Child and Adolescent Psychiatry, American Psychiatric Press. 389–410.External Source Document
Wasserstein J. Diagnostic issues for adolescents and adults with ADHD. J Clin Psychol 2005; 61: 535–47.External Source Document
Wilens TE, Faraone SV, Biederman J, Gunawardene S. Does stimulant therapy of attention-deficit/hyperactivity disorder beget later substance abuse? A meta-analytic review of the literature. Pediatrics 2003; 111: 179–85.External Source Document
Wolraich ML, Hannah JN, Pinnock TY, Baumgaertel A, Brown J. Comparison of diagnostic criteria for attention-deficit hyperactivity disorder in a county-wide sample. J Am Acad Child Adolesc Psychiatry 1996; 35: 319–24.Wong DT, Threlkeld PG, Best KL, Bymaster FP. A new inhibitor of norepinephrine uptake devoid of affinity for receptors in rat brain. J Pharmacol Exp Ther 1982; 222: 61-5.
Alzheimers Disease
Danysz W., and Parsons C.G. (2003) The NMDA receptor antagonist memantine as a symptomatological and neuroprotective treatment for Alzheimer's disease: preclinical evidence. Int J Geriatr Psychiatry 18(Suppl 1): 23-32.External Source Document | Internal Use Of This Reference
Danysz W., Parsons C., Möbius H.J., Stöffler A., and Quack G. (2000) Neuroprotective and symptomatological action of memantine relevant for Alzheimer’s Disease – A unified glutamatergic hypothesis of the mechanism of action. Neurotox Res Vol. 2: 85-97.Doody R, Wirth Y, Schmitt F, Möbius HJ. Specific functional effects of memantine treatment in patients with moderate to severe Alzheimer’s disease. Dement Geriatr Cogn Disord 18: 227-232, 2004.External Source Document | Internal Use Of This Reference
Durlach J. (1990) Magnesium depletion and pathogenesis of Alzheimer's disease. Magnes Res 3: 217-8.External Source Document | Internal Use Of This Reference
Durlach J., Durlach V., Bac P, Bara M, and Guiet-Bara A. (1994) Magnesium and therapeutics. Magnes Res. 3-4: 313-28.External Source Document | Internal Use Of This Reference
Fawcett W.J., Haxby E.J., and Male D.A. (1999) Magnesium: physiology and pharmacology. Br J Anaesth. 83(2): 302-20.External Source Document | Internal Use Of This Reference
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Gauthier S, Wirth Y and Möbius HJ. Effects of Memantine on behavioural symptoms in Alzheimer’s disease patients: an analysis of the Neuropsychiatric Inventory (NPI) data of two randomised, controlled studies. Int J Geriat Psychiatr 20: 1-6, 2005. f.External Source Document | Internal Use Of This Reference
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Hartmann S, Möbius HJ. Tolerability of memantine in combination with cholinesterase inhibitors in dementia therapy. Int Clin Psychopharmacol 18: 81-85, 2003.External Source Document | Internal Use Of This Reference
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Miguel-Hidalgo J.J., Alvarez X.A., Cacabelos R., and Quack G. (2002) Neuroprotection by memantine against neurodegeneration induced by beta-amyloid(1-40). Brain Res 958(1):210-21.External Source Document | Internal Use Of This Reference
Miguel-Hidalgo JJ, Alvarez XA, Cacabelos R, Quack G. Neuroprotection by memantine against neurodegeneration induced by beta-amyloid (1-40). Brain Res. 958:210-221, 2002.External Source Document | Internal Use Of This Reference
Misztal M, Frankiewicz T, Parsons CG, and Danysz W. (1996) Learning deficits induced by chronic intraventricular infusion of quinolinic acid-protection by MK-801 and memantine. Eur J Pharmacol 296(1):1-8.External Source Document | Internal Use Of This Reference
Misztal. M, Frankiewicz T, Parsons CG, Danysz W. Learning deficits induced by chronic intraventricular infusion of quinolinic acid – protection by MK-801 and memantine. Eur J Pharmacol; 296: 1-8, 1996.External Source Document | Internal Use Of This Reference
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Parsons CG, Danysz W, Quack G. Memantine is a clinically well tolerated N-methyl-D-aspartate (NMDA) rezeptor antagonist – a review of preclinical data. Neuropharmacology; 38:735 – 767, 199.External Source Document | Internal Use Of This Reference
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Arthritis
Jordan K M, Arden N K, Doherty M, Bannwarth B, et al.: EULAR Recommendations 2003: an evidence based approach to the management of knee osteoarthritis: Report of a Task Force of the Standing Committee for International Clinical Studies Including Therapeutic Trials (ESCISIT). Ann Rheum Dis 2003;62;1145-1155. doi:10.1136/ard.2003.011742.External Source Document | Internal Use Of This Reference
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Jordan K M, Arden N K, Doherty M, Bannwarth B, et al.: EULAR Recommendations 2003: an evidence based approach to the management of knee osteoarthritis: Report of a Task Force of the Standing Committee for International Clinical Studies Including Therapeutic Trials (ESCISIT). Ann Rheum Dis 2003;62;1145-1155. doi:10.1136/ard.2003.011742.External Source Document | Internal Use Of This Reference
Asthma
Abramson MJ, Bailey MJ, Couper FJ, Driver JS, Drummer OH, Forbes AB, et al. Are asthma medications and management related to deaths from asthma? Am J Respir Crit Care Med 2001;163:12–18.External Source Document | Internal Use Of This Reference
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Bahceciler NN, Nuhoglu Y, Nursoy MA, Kodalli N, Barlan IB, Basaran MM. Inhaled corticosteroid therapy is safe in tuberculin-positive asthmatic children. Pediatr Infect Dis J 2000;19:215-8.External Source Document | Internal Use Of This Reference
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