Thrombosis Adviser

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Understanding Venous and arterial thrombosis: a major global health concern
From public health scares about the risk of deep vein thrombosis (DVT) on long-distance flights to high rates of pulmonary embolism (PE) in patients recovering from major surgery, venous thromboembolism (VTE) is a well-publicised, serious health issue. ^{1, 2}
Learn more about venous and arterial thrombosis…

Knowing the Risk - The significant impact of venous thromboembolism (VTE)
Thrombosis, the formation of a blood clot within the circulatory system, is a leading cause of death and disability.  Up to 15% of patients hospitalised for an acute medical illness develop venous thromboembolic disease.³
Learn more about the risks associated with VTE...

Current Treatments - VTE prevention: available therapies are underused
There are several pharmaceutical options for the prevention and treatment of thrombosis. Limitations of these medications, however, contribute to their under utilisation in many countries.¹
Learn more about current anticoagulant and antiplatelet treatments and why there is a pressing need for new approaches to treatment and prevention...⁴

New Approaches in Anticoagulation Therapy - Progress in the prevention and treatment of thromboembolic disease
The search for an ideal anticoagulant is motivated by the well-known shortcomings of currently available anticoagulants. Current therapies, such as heparins and vitamin K antagonists (VKAs), have a number of clinically relevant limitations contributing to underuse by clinicians worldwide. ^{5, 6, 7}
Learn more about new agents that are in development and their advantages...

Resources
A wealth of useful resources including an image library, recommended reading, thrombosis news, downloadable documents and useful websites.
Access these useful resources.

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What's in the Thrombosis Adviser website?

• Understanding Thrombosis
• Haemostasis
• Coagulation Cascade
• How Thrombosis Develops
• How Venous Thrombosis Occurs
• Thrombosis and Atrial Fibrillation
• Thrombosis and Acute Coronary Syndrome
• Diagnosing Thrombosis
• Diagnosing Deep Vein Thrombosis
• Diagnosing Pulmonary Embolism
• Diagnosing Thrombosis in Atrial Fibrillation
• Diagnosing Acute Coronary Syndrome
• Knowing the Risk
• VTE Risk in Surgical Patients
• VTE Risk in Medical Patients
• Long-Term Complications of VTE
• VTE Risk Assessment Guide
• Atrial Fibrillation and Cardioembolic Stroke
• Acute Coronary Syndrome
• Current Treatments
• Anticoagulants
• Vitamin K Antagonists
• Heparins
• Single Coagulation Factor Inhibitors
• Antiplatelet Drugs
• Mechanical Devices
• Current Approaches to Antithrombotic Therapy
• VTE Prevention in Surgical Patients
• VTE Prevention in Medical Patients
• Treatment of Established DVT and PE
• Stroke Prevention in AF
• Acute Treatment and Prevention of ACS
• New Approaches
• New Anticoagulation Targets
• New Targets for Platelet Inhibition
• Resources
• Publications
• Thrombosis Image Library
• Free Downloads
• Poll Archive
• Recommended Websites
• Thrombosis News Ticker

References:
1. Lapostolle F, Surget V, Borron SW, et al. Severe pulmonary embolism associated with air travel. N Engl J Med. 2001;345(11):779-783.
2. Moll S, Mackman N. Venous thromboembolism: a need for more public awareness and research into mechanisms. Arterioscler Thromb Vasc Biol. 2008;28(3):367-369.
3. Tapson VF, Decousus H, Pini M, et al; IMPROVE Investigators. Venous thromboembolism prophylaxis in acutely ill hospitalized medical patients: findings from the International Medical Prevention Registry on Venous Thromboembolism. Chest. 2007;132(3):936-945.
4. Geerts WH, Bergqvist D, Pineo GF, Heit JA, Samama CM, Lassen MR, and Colwell CW. Prevention of Venous Thromboembolism: American College of Chest Physicians (ACCP) Evidence-Based Clinical Practice Guidelines (8th Edition). Chest. Jun 2008: 381S–453S.
5. Cohen AT, Tapson VF, Bergmann JF, et al; ENDORSE Investigators. Venous thromboembolism risk and prophylaxis in the acute hospital care setting (ENDORSE study): a multinational cross-sectional study. Lancet. 2008;371(9610):387-394.
6. Haas S. New oral Xa and IIa inhibitors: updates on clinical trial results. J Thromb Thrombolysis. 2008;25(1):52-60.
7. Ansell J. Factor Xa or thrombin: is factor Xa a better target? J Thromb Haemost. 2007;5(suppl 1):60-64.