ACEPRIL , Captopril - hypertension/diabetes, Tablets, captopril 12.5mg , 25m, Medicine and Disease information

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ACEPRIL overview

Mild to moderate hypertension. Severe hypertension where standard therapy is ineffective or inappropriate. Diabetic nephropathy in insulin dependent diabetes.

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Related DrugsDrug Details

ACEPRIL

Drug Class Description :

ACE inhibitors.

Generic Name :

Captopril - hypertension/diabetes

Drug description :

12.5 mg, white scored capsule- shaped tablet marked ACE and 12.5; 25 mg, 50 mg white scored tablets marked ACE and tablet strength.

Presentation :

Tablets, captopril 12.5mg , 25mg , 50mg .

Indications :

Mild to moderate hypertension. Severe hypertension where standard therapy is ineffective or inappropriate. Diabetic nephropathy in insulin dependent diabetes.

Adult Dosage :

Mild to moderate hypertension
Initially 12 .5 mg twice daily. Maintenance, 25 mg twice daily increasing gradually at 2 - 4 week intervals if necessary to maximum 50 mg twice daily.

Severe hypertension
Initially 12.5 mg twice daily increasing if necessary to maximum 50 mg three times daily. Diabetic nephropathy, 75 - 100 mg daily in divided doses.

Child Dosage :

Contact manufacturer.

Contra Indications :

Obstruction
Pregnancy
lactation.

Special Precautions :

Renovascular hypertension
severe congestive heart failure. Haemodialysis.

Renal impairment
monitor renal function, white cell count and urinary protein before and during therapy.

Collagen vascular disease
Anaesthesia. Elderly.

Interactions :

K+-sparing diuretics or K+ supplements
NSAIDs
vasodilators
clonidine
allopurinol
procainamide
probenecid
immunosuppressants
lithium
antidiabetic agents
neuroleptics
tricyclic antidepressants
antihypertensives.

Adverse Reactions :

Neutropenia
Agranulocytosis
Thrombocytopenia
Anaemia
Proteinuria
Hypotension
Angioedema
Rash
Loss of taste
Pancreatitis
Tachycardia
Gastric irritation
Cough (rare).

Manufacturer :

Bristol-Myers Squibb / Ashbourne

Drug Availability :

(POM)

Drug Updated :

22 June 2009

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