HOMEwww.epgonline.orgDRUGSwww.epgonline.orgDISEASE KNOWLEDGEwww.epgonline.orgGUIDELINESwww.epgonline.orgCLINICAL TRIALSwww.epgonline.orgREGISTERwww.epgonline.orgSEARCH
Members
Why a doctor should
Username/Email

Password ()




EPG on Twitter EPG Online Twitter
EPG Online Blog EPG Online Blog
EPG Online Disease Knowledge Centres Feed Disease Knowledge
Recent UK Drug Updates Drug Updates
EPG Search
Search
Languages

HELICLEAR overview
Eradication of Helicobacter pylori in patients with duodenal ulcers
banner_pass = 1

Please register to access disease diagnosis, patient management, physician tools.
By viewing the content of this web page you are both confirming your status as a healthcare professional and agreeing to our terms of use.

Change language Current language database: English
 
 
Related DrugsDrug Details
HELICLEAR
Drug Class Description :

Proton pump inhibitors (PPIs) / macrolides / broad spectrum penicillins (antibiotics).

Generic Name :

Lansoprazole, clarithromycin, amoxicillin [amoxycillin]

Drug description :

Zoton Capsules: lilac/purple capsules marked with strength and company name. Klaricid Tablets: yellow oval f-c tablets with logo. Amoxycillin Capsules: capsules.

Presentation :

Treatment pack containing 14 Zoton (lansoprazole) capsules, 14 Klaricid (clarithromycin) 500mg tablets, 28 amoxicillin 500mg capsules.

Indications :

Eradication of Helicobacter pylori in patients with duodenal ulcers

Adult Dosage :

1 x Zoton capsule, 1 x Klaricid tablet and 2 x amoxycillin capsules all twice daily for seven days.

Child Dosage :

Not recommended

Contra Indications :

Severe renal impairment. Pregnacy

Special Precautions :

Exclude malignacy pror to treatment. Renal or hepatic treatment. Renal or hepatic impairment. Lactation

Interactions :

Drugs metabolised by cytochrome P450 system (eg, warfarin, ergot alkaloids, triazolam, midazolam, disopyramide, lovastatin, rifabutin, phenytoin and cyclosporin). Rhabdomyolysis, coincident with the co- administration of clarithromycin, and HMG-CoA reductase inhibitors, such as lovastatin and simvastatin has been reported.

Theophylline, oral anticoagulants, digoxin, carbamazepine, ritonavir, zidovudine, statins, phenytoin, antacids, sulcrafate, oral contraceptives.

Adverse Reactions :

Amoxycillin : GI upset, hypersensitivity reactions. Clarithromycin : GI upset, paraesthesia, stomatitis, glossitis, oral monilia, tongue and tooth discolouration, headache, arthralgia, myalgia, and allergic reactions ranging from urticaria and mild skin eruptions and angioedema to anapyhlaxis and rarely Stevens- Johnson syndrome.

Hepatic dysfunction, reversible hearing loss. Rarely, pseudomembranous colitis, hypoglycaemia, leucopenia, thrombocytopenia, renal dysfunction, interstitial nephritis, and renal failure. QT prolongation, ventricular tachycardia and Torsades de Pointes have been reported rarely.

Lansoprazole: Headache, dizziness, fatigue, malaise, GI upset, sore throat, skin irritation, hypersensitivity reactions, raised liver function values, jaundice, hepatitis, increased risk of GI infections. Rarely arthralgia, myalgia, peripheral oedema, haematological changes, erythmatous or bullous rashes, photosensitivity, interstitial nephritis, confusion, hallucinations, gynaecomastia, impotence.

Manufacturer :

Wyeth

Drug Availability :

(POM)

Drug Updated :

14 May 2009

Related Drugs - Acid-peptic & motility disorders
Male hypogonadism is the term used to describe decreased functional activity of the testes with diminished production and action of testosterone. Advancing Immunotherapy in Oncology Chronic Kidney Disease (CKD) is characterised by a gradual and permanent loss of kidney function that worsens as it progresses from stages 1 to 5. One of the most common complications of CKD is anaemia. Parkinson's disease (PD) is a degenerative disorder of the central nervous system characterized by the clinically asymmetric onset of resting tremor, bradykinesia, rigidity and postural instability.
New and updated Drugs
UK Drugs EPG Medical News Feed
Spanish Drugs EPG Medical News Feed
German Drugs EPG Medical News Feed
Norweigan Drugs EPG Medical News Feed
Netherlands Drugs EPG Medical News Feed
Swedish Drugs EPG Medical News Feed
French Drugs EPG French Drugs Feed
Portuguese Drugs EPG Portuguese Drugs Feed
Italian Drugs EPG Italian Drugs Feed

Atopic Dermatitis

Atopic Dermatitis

CONNECT

DISEASE CENTRES Disease Centres feed

AFFILIATE PARTNERS

QUICK SEARCH

GUIDELINES UK Drug Data Feed

DRUG DATA UK Drug Data Feed

REFERENCES