ALPHAPARIN, Certoparin, Injection, certoparin 3000 i.u. anti-Facto, Medicine and Disease information

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ALPHAPARIN overview

Prophylaxis of peri- and post- operative venous thromboembolism.

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ALPHAPARIN

Drug Class Description :

Low molecular weight heparins (LMWHs, anticoagulants).

Generic Name :

Certoparin

Drug description :

Solution in pre-filled syringes.

Presentation :

Injection, certoparin 3000 i.u. anti-Factor Xa activity.

Indications :

Prophylaxis of peri- and post- operative venous thromboembolism.

Adult Dosage :

3000 i.u. daily by subcutaneous injection into the peritoneal fold 1 - 2 hours prior to surgery. Repeat once daily for 7 to 10 days or until mobile.

Child Dosage :

Not recommended.

Contra Indications :

Major bleeding disorders, bleeding ulcers of the stomach or intestine, severe hypertension (>200/120mmHg), hypersensitivity to heparin, subacute bacterial endocarditis, severe renal and/or hepatic dysfunction.

Special Precautions :

Must not be administered intramuscularly. Monitor platelet counts. May cause hyperkalaemia, particularly in diabetes mellitus, chronic renal failure, mellitus, chronic renal failure, pre-existing metabolic acidosis, patients with raised plasma potassium or taking potassium- sparing drugs; measure plasma potassium before starting therapy, and monitor regularly thereafter, especially if treatment prolonged beyond 7 days. Spinal or epidural anaesthesia - risk of spinal haematomas and paralysis; observe patients carefully. Pregnancy and lactation.

Interactions :

NSAIDs, oral anticoagulants, dipyridamole, dextrans, etacrynic acid (ethacrynic acid), cytostatic agents, antihistamines, digitalis, tetracyclines, ascorbic acid.

Adverse Reactions :

Minor bleeding at injection site, thrombocytopenia, hypersensitivity reactions, raised liver enzymes, osteoporosis. Rarely, clinically significant hyperkalaemia. Very rarely, spinal haematomas in patients undergoing spinal or epidural anaesthesia.

Manufacturer :

Grifols

Drug Availability :

(POM)

Drug Updated :

04 June 2009

Related Drugs - Anticoagulants, antithrombotics & fibrinolytics

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