APO-GO, Apomorphine, Solution for injection, apomorphine hydrochlorid, Medicine and Disease information

Members

Why a doctor should join epgonline.org ?

EPG Online Twitter

EPG Online Blog

Disease Knowledge

Drug Updates

EPG Search

APO-GO overview

Treatment of disabling motor fluctuations in patients with Parkinson's disease which persist after treatment with levodopa and/or other dopamine agonists.

Social Networks

Drug Updates

banner_pass = 1

Please register to access disease diagnosis, patient management, physician tools.
By viewing the content of this web page you are both confirming your status as a healthcare professional and agreeing to our terms of use.

Change language Current language database: English

Related DrugsDrug Details

APO-GO

Drug Class Description :

Dopamine agonists (dopaminergics) .

Generic Name :

Apomorphine

Drug description :

Solution for injection in 2mL or 5mL ampoules.

Presentation :

Solution for injection, apomorphine hydrochloride 1.0% w/ v (10mg/mL).

Indications :

Treatment of disabling motor fluctuations in patients with Parkinson's disease which persist after treatment with levodopa and/or other dopamine agonists.

Adult Dosage :

For subcutaneous use by intermittent bolus injection. May also be administered as a continuous subcutaneous infusion by minipump. It is essential that the patient is established on domperidone, usually 20mg three times daily for at least two days prior to initiation of therapy.

Child Dosage :

Under 18 years, contraindicated.

Contra Indications :

Respiratory depression, dementia, hepatic insufficiency. hepatic insufficiency. Intermittent apomorphine treatment is not suitable for patients who have an 'on' response to levodopa which is marred by severe dyskinesia or dystonia. Known sensitivity to apomorphine or to any other ingredients of the product. Not recommended for use in women of child-bearing potential. Breastfeeding not recommended.

Special Precautions :

Renal, pulmonary or cardiovascular disease. Persons prone to nausea and vomiting. Elderly and/or debilitated patients. Pre-existing cardiac disease, patients taking vasoactive drugs such as antihypertensives, pre-existing postural hypotension.

Neuropsychiatric disturbance may be exacerbated by APO-go in some patients; there is also evidence from clinical studies that APO-go may improve these symtoms.

Interactions :

Neuroleptics, antihypertensives, cardiac active drugs.

Adverse Reactions :

Nausea and vomiting. Postural hypotension. Local subcutaneous injection site reactions including local induration and nodules (usually asymptomatic). Dyskinesia, neuropsychiatric disturbances. Transient sedation. Rarely, Coomb's positive haemolytic anaemia in patients treated with apomorphine and levodopa. Eosinophilia.

Manufacturer :

Britannia

Drug Availability :

(POM)

Drug Updated :

30 June 2009

Related Drugs - Neurodegenerative diseases

Male hypogonadism is the term used to describe decreased functional activity of the testes with diminished production and action of testosterone.

The prognosis of patients with diabetes is improved by interventions that reduce HbA1C

Disease Knowledge – evidence based educational and clinical tools written for doctors and physicians

Disease Knowledge Centres feed

New and updated Drugs

UK Drugs
Fostair 100/6 inhalation solution Epanutin capsules 25, 50 and 100mg Eprex 2000, 4000 and 10000 IU/ml solution for injection in pre-filled syringe FemSeven Conti Epanutin 300mg hard capsules Bedranol 80mg SR Capsules Bedranol 160mg SR Capsules Betim 10mg Tablets Carbo-Dome Cream Bisoprolol 2.5mg/5mg/10mg film coated tablet	Phenergan Injection Rivotril 0.5 mg and 2 mgTablets Rivotril Ampoules RELPAX 20mg and 40mg Film-Coated Tablets Witch Doctor ® 81.5%w/w Gel Levetiracetam Actavis 1,000 mg film-coated tablets Levetiracetam Actavis 250 mg film-coated tablets Levetiracetam Actavis 500 mg film-coated tablets Levetiracetam Actavis 750 mg film-coated tablets Lidocaine Hydrochloride Injection BP 1% w/v plastic ampoules

Spanish Drugs
Benlysta 400 mg polvo para concentrado para solución para perfusión. Benlysta 120 mg polvo para concentrado para solución para perfusión. Qutenza 179 mg parche cutáneo MULTAQ 400 mg comprimidos recubiertos con película Onglyza 2,5 mg comprimidos recubiertos con película IRESSA 250 mg comprimidos recubiertos con película Mycamine 50 mg polvo para solución para perfusión Protopic 0,03% pomada Protopic 0,1% pomada Cayston 75 mg polvo y disolvente para solución para inhalación por nebulizador	Altargo 1% pomada Xarelto 15 mg comprimidos recubiertos con película Xarelto 10 mg comprimidos recubiertos con película Xarelto 20 mg comprimidos recubiertos con película BRINAVESS 20 mg/ml, concentrado para solución para perfusión MEPACT 4 mg polvo para suspensión para perfusión. Fablyn Nebido 1000mg/4ml Testogel Nebido

German Drugs
Benlysta 120 mg Pulver zur Herstellung eines Infusionslösungskonzentrats. Benlysta 400 mg Pulver zur Herstellung eines Infusionslösungskonzentrats. MULTAQ® 400 mg Filmtabletten Qutenza 179 mg kutanes Pflaster Onglyza 2,5 mg Filmtabletten Protopic 0,1% Salbe IRESSA 250 mg Filmtabletten Mycamine 50 mg Pulver zur Herstellung einer Infusionslösung Vistide 75 mg/ml Konzentrat zur Herstellung einer Infusionslösung Cayston 75 mg Pulver und Lösungsmittel zur Herstellung einer Lösung für einen Vernebler	Protopic 0,03% Salbe Xarelto 20 mg Filmtabletten Xarelto 15 mg Filmtabletten Xarelto 10 mg Filmtabletten Mycophenolatmofetil Teva 250 mg Hartkapseln Humira 40 mg MEPACT 4 mg Pulver zur Herstellung einer Infusionssuspension FABLYN Testogel Nebido 1000mg/4ml

Norweigan Drugs
Benlysta 120 mg pulver til konsentrat til infusjonsvæske, oppløsning. Benlysta 400 mg pulver til konsentrat til infusjonsvæske, oppløsning. Qutenza 179 mg hudplaster Onglyza 2,5 mg filmdrasjerte tabletter. IRESSA 250 mg, filmdrasjerte tabletter Protopic 0,1 % salve Mycamine 50 mg pulver til infusjonsvæske, oppløsning Cayston 75 mg pulver og væske til inhalasjonsvæske til nebulisator, oppløsning Xarelto 20 mg tabletter, filmdrasjerte Xarelto 15 mg tabletter, filmdrasjerte	Xarelto 10 mg tabletter, filmdrasjerte Fungizone Kabikinase Insulin Insulatard Flunitec Insulin Monotard Insulin Mixtard 50/50 Insulin Mixtard 40/60 Hivid Insulin Mixtard 20/80

Netherlands Drugs
Benlysta 120 mg poeder voor concentraat voor oplossing voor infusie. Benlysta 400 mg poeder voor concentraat voor oplossing voor infusie. Qutenza 179 mg huidpleister Onglyza 2,5 mg, filmomhulde tabletten IRESSA 250 mg filmomhulde tabletten Mycamine 50 mg poeder voor oplossing voor infusie Protopic 0,1% zalf Cayston 75 mg poeder en oplosmiddel voor verneveloplossing Protopic 0,03% zalf Xarelto 20 mg filmomhulde tabletten	Xarelto 15 mg filmomhulde tabletten Xarelto 10 mg filmomhulde tabletten Polyspectran Tobrex Tetracycline Oogdruppels FNA Zarontin Gentamytrex Ethymal Irgamid Polytrim
Swedish Drugs
Benlysta 400 mg pulver till koncentrat till infusionsvätska, lösning. Benlysta 120 mg pulver till koncentrat till infusionsvätska, lösning. Qutenza 179 mg kutant plåster Onglyza 2,5 mg filmdragerade tabletter IRESSA 250 mg filmdragerade tabletter Mycamine 50 mg pulver till infusionsvätska, lösning Protopic 0,1% salva Cayston 75 mg pulver och vätska till lösning för nebulisator Xarelto 15 mg filmdragerade tabletter Xarelto 20 mg filmdragerade tabletter	Xarelto 10 mg filmdragerade tabletter Ketek 400 mg filmdragerade tabletter Tasigna 200 mg hårda kapslar Advate Injektionsvätska, lösning Axura 10 mg/g orala droppar, lösning Axura 10 mg filmdragerade tabletter Myozyme 50 mg, pulver till koncentrat till infusionsvätska, lösning Onbrez Breezhaler 300 mikrogram inhalationspulver, hårda kapslar Hepsera 10 mg tabletter Champix filmdragerade tabletter

French Drugs
Benlysta 120 mg poudre pour solution à diluer pour perfusion. Benlysta 400 mg poudre pour solution à diluer pour perfusion Qutenza 179 mg patch cutané. Onglyza 2,5 mg, comprimés pelliculés IRESSA 250 mg, comprimés pelliculés Mycamine 50 mg poudre pour solution pour perfusion Protopic 0,1% pommade VISTIDE 75 mg/ml, solution à diluer pour perfusion CANCIDAS 50 mg poudre pour solution à diluer pour perfusion Cubicin 350 mg poudre pour solution à diluer pour perfusion	ECALTA 100 mg poudre et solvant pour solution à diluer pour perfusion Altargo 1% pomada Protopic 0,03% pommade Xarelto 20 mg comprimé pelliculé Xarelto 15 mg comprimé pelliculé Xarelto 10 mg comprimé pelliculé Herceptin 150 mg poudre pour solution à diluer pour perfusion ACETYLCYSTEINE BIOGARAN CONSEIL 200 mg, poudre pour solution buvable en sachet ACETYLLEUCINE BIOGARAN 500 mg, comprimé ACETYLLEUCINE ZENTIVA 500 mg, comprimé

Portuguese Drugs
Benlysta 400 mg pó para concentrado para solução para perfusão Benlysta 120 mg pó para concentrado para solução para perfusão. Qutenza 179 mg adesivo cutâneo Onglyza 2,5 mg comprimidos revestidos por película IRESSA 250 mg comprimidos revestidos por película Protopic 0,1% pomada Mycamine 50 mg pó para solução para perfusão Vistide 75 mg/ml concentrado para solução para perfusão ECALTA 100 mg pó e solvente para concentrado para solução para perfusão CANCIDAS 50 mg pó para concentrado para solução para perfusão	Cubicin 350 mg pó para solução injetável ou para perfusão Protopic 0,03% pomada Xarelto 20 mg comprimidos revestidos por película Xarelto 15 mg comprimidos revestidos por película Xarelto 10 mg comprimidos revestidos por película Tredaptive Truvada Trevaclyn Trisenox Trizivir

Italian Drugs
Benlysta 400 mg polvere per concentrato per soluzione per infusione. Benlysta 120 mg polvere per concentrato per soluzione per infusione Qutenza 179 mg cerotto cutaneo Onglyza 2,5 mg compresse rivestite con film Mycamine 50 mg polvere per soluzione per infusione Vistide 75 mg/ml concentrato per soluzione per infusione CANCIDAS 50 mg polvere per concentrato per soluzione per infusione ECALTA 100 mg polvere e solvente per concentrato per soluzione per infusione Cubicin 350 mg polvere per soluzione iniettabile o per infusione Altargo 1% unguento	Protopic 0,03% unguento Xarelto 20 mg compresse rivestite con film Xarelto 15 mg compresse rivestite con film Xarelto 10 mg compresse rivestite con film MEPACT 4 mg polvere per sospensione per infusione FABLYN Testogel Nebido Levitra Xelevia 25 mg compresse rivestite con film

Atopic Dermatitis

CONNECT

DISEASE CENTRES

AFFILIATE PARTNERS

QUICK SEARCH

GUIDELINES

DRUG DATA

REFERENCES