Azathioprine (rheumatoid arthritis), Generic, Tablet, Medicine and Disease information

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Azathioprine (rheumatoid arthritis) overview

Severe rheumatoid arthritis.

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Azathioprine (rheumatoid arthritis)

Drug Class Description :

Cytotoxic immunosuppressants (DMARDs).

Generic Name :

Generic

Drug description :

Tablets, azathioprine 25mg , 50mg . Available from APS, Ashbourne (Immunoprin R ), Cox, Generics UK, Genus, Hillcross, Lagap, Norton, Opus (Oprisine R ).

Presentation :

Tablet

Indications :

Severe rheumatoid arthritis.

Adult Dosage :

Initially, 1 - 3mg/kg daily then reduce to maintenance; if no response after three months, consider withdrawal.

Child Dosage :

As for adults.

Contra Indications :

Hypersensitivity to azathioprine or mercaptopurine.

Special Precautions :

Monitor for toxic effects especially blood counts. Patients should be advised to report any evidence of infection, unexpected bruising or bleeding, or other manifestations of bone marrow suppression. Impaired renal or hepatic function. Pregnancy and lactation. Undue sun exposure.

Interactions :

Allopurinol, cytostatic/ myelosuppressive agents, muscle relaxants, warfarin.

Adverse Reactions :

Myelosuppression, hepatotoxicity, GI distress, rash, hypersensitivity reactions (including general malaise, dizziness, nausea, vomiting, diarrhoea, fever). Alopecia. Rarely, pancreatitis, pneumonitis.

Drug Availability :

(POM)

Drug Updated :

26 June 2009

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