NEBCIN, Tobramycin, Injection, tobramycin (as sulphate) 20, Medicine and Disease information

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NEBCIN overview

Treatment of the following infections caused by susceptible micro-organisms: central nervous system infections (including meningitis, septicaemia and neonatal sepsis); gastrointestinal infections (including peritonitis, complicated and recurrent urinary tract infections); lower respiratory tract infections (including pneumonia, bronchopneumonia and acute bronchitis); skin, bone and soft tissue infections (including burns).

Tobramycin is usually active against most strains of the following organisms: Pseudomonas aeruginosa; Proteus species (indole positive and indole negative), including Pr. mirabilis, Pr. rettgeri and Pr. vulgaris; Morganella morganii; vulgaris; Morganella morganii; Escherichia coli; Klebsiella- Enterobacter-Serratia species; Citrobacter species; Providencia species; Staphylococci including Staphylococcus aureus (coagulase-positive and coagulase-negative).

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NEBCIN

Drug Class Description :

Aminoglycosides.

Generic Name :

Tobramycin

Drug description :

Solution in vials.

Presentation :

Injection, tobramycin (as sulphate) 20, 40 and 80 mg .

Indications :

Adult Dosage :

3 - 5 mg/kg daily in three or four divided doses by intramuscular injection or intravenous injection or infusion.

Child Dosage :

Neonates, up to 4 mg/kg daily in two equal doses; others, 6 - 7.5 mg/kg daily in three or four divided doses.

Contra Indications :

Pregnancy, lactation.

Special Precautions :

Renal impairment; control blood levels and dosage.

Interactions :

Other aminoglycosides, loop diuretics, neuromuscular blocking agents.

Adverse Reactions :

Anaphylaxis, ototoxicity, nephrotoxicity. Raised liver enzymes.

Manufacturer :

King

Drug Availability :

(POM)

Drug Updated :

24 June 2009

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