Acea 0.75% w/w Gel, Metronidazole 0.75% w/w, Gel. Clear very pale yellow ge, Medicine and Disease information

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Acea 0.75% w/w Gel overview

The treatment of acute inflammatory exacerbations of rosacea.

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Acea 0.75% w/w Gel

Generic Name :

Metronidazole 0.75% w/w

Drug description :

Acea 0.75% w/w Gel Metronidazole 0.75% w/w Gel

Presentation :

Gel. Clear very pale yellow gel.

Indications :

The treatment of acute inflammatory exacerbations of rosacea.

Adult Dosage :

For cutaneous use only.

(i) For adults and the elderly. Apply the gel to the affected area of the skin in a thin film twice daily for 8 weeks. Thereafter further applications may be necessary depending on the severity of the condition.

(ii) For Children. Not recommended.

Child Dosage :

For cutaneous use only.

(ii) For Children. Not recommended.

Elderly Dosage :

For cutaneous use only.

(ii) For Children. Not recommended.

Contra Indications :

Known hypersensitivity to metronidazole, parabens or any of the constituents.

Special Precautions :

Warnings: Avoid contact with the eyes. If contact with the eyes occurs the gel should be washed out carefully with water.

Precautions: The following statements take into account the possibility that metronidazole may be absorbed after topical application. However there is no evidence of any significant systemic concentrations of metronidazole following topical applications. Peripheral neuropathy has been reported in association with prolonged use of oral metronidazole. The elimination half-life of metronidazole remains unchanged in the presence of renal failure. Such patients, however, retain the metabolite of metronidazole. The clinical significance of this is not known at present. However in patients undergoing haemodialysis, metronidazole and its metabolites are efficiently removed.

Contains methyl parahydroxybenzoate (E218) and propyl parahydroxybenzoate (E216) and ethyl parahydroxybenzoate (E214), may cause allergic reactions (possibly delayed).

Interactions :

Patients are advised not to take alcohol during systemic metronidazole therapy because of the possibility of a disulfiram-like reaction.

Some potentiation of anti-coagulant therapy has been reported when metronidazole has been used with the warfarin type oral anticoagulants.

Patients receiving phenobarbitone metabolise metronidazole at a much faster rate than normal, reducing the half-life to 3 hours.

Adverse Reactions :

Dryness or irritation of the skin may be experienced after application to unbroken skin. Systemic metronidazole therapy may occasionally cause an unpleasant taste in the mouth, furred tongue, nausea, vomiting, gastro-intestinal disturbance, urticaria, angioedema and anyphylaxis. Drowsiness, dizziness, headache, ataxia, skin rash, pruritis and darkening of urine has been reported, but rarely.

Manufacturer :

Ferndale Pharmaceuticals Ltd. 12 York Place, Leeds, LS1 2DS, United Kingdom.

Owner :

Ferndale Pharmaceuticals

Drug Availability :

Drug Updated :

10 November 2011

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