The clinical phenotype typical of atopic dermatitis is the result of a combination of complex interactions between environmental factors, susceptibility genes, defects in skin barrier function and immunological responses.25
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Reference:
25. Maintz L, Novak N. Getting more and more complex: the pathophysiology of atopic eczema. Eur J Dermatol 2007; 17: 267-83.
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The Atopic Dermatitis Knowledge centre contained within www.epgonline.org and available at www.atopicdermatitisinfo.org is intended to be for educational use only and not designed to provide medical advice or professional services.