Aetiology

Hepatitis C Virus Genotypes

There are six major HCV genotypes (designated 1 to 6) and multiple subtypes (designated a, b, c, etc.) and their global distribution varies (Zein, 2000) (Figure 1-4). Recent demographic shifts in particular genotypes have been observed. In London (UK) the prevalence of genotype 3 has risen and genotype 4 has recently emerged in France due to immigration from countries where these genotypes prevail. Identification of the infecting genotype is important, not only for epidemiological reasons, but also because the optimal regimen and response to treatment vary according to genotype.  

Figure 1-4. Global geographical distribution of HCV genotypes (Zein, 2000).

Global geographical distribution of HCV genotypes

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