Treatment Options
Levitra- Erectile Dysfunction & Radical Prostatectomy
Levitra helps men with ED following nerve-sparing radical prostatectomy: the REINVENT study1
- Randomised, double-blind, double-dummy, multicentre, parallel-group study in men immediately (within 14 days) following bilateral nerve-sparing radical prostatectomy (NSRP)
- A well designed study investigating PDE-5 inhibitor therapy for recovery of erectile function in men following bilateral NSRP:
- Rigorous in design and blinding
- Large study sample (n=628)
- Designed to reflect the real-life population of patients undergoing bilateral NSRP surgery
- Levitra on-demand showed good efficacy in this notoriously difficult-to-treat patient population with ED, and is effective soon after NSRP
NSRP, nerve-sparing radical prostatectomy; PDE-5, phosphodiesterase type 5
Study Design Overview
REINVENT: Levitra on-demand restores erectile function in men with ED following bilateral NSRP1
*p≤0.0001 for Levitra on-demand vs placebo; ◊p<0.01 for Levitra on-demand vs nightly; **p=0.0144 for Levitra nightly vs placebo (for all secondary variables, p<0.05 considered to be nominally significant); IIEF-EF, International Index of Erectile Function, erectile function domain; NSRP, nerve-sparing radical prostatectomy
REINVENT: Levitra on-demand improves rates of successful intercourse completion in men with ED following bilateral NSRP1
*p≤0.0001 for Levitra on-demand vs placebo; ◊p<0.0114 for Levitra on-demand vs nightly; **p=0.0344 for Levitra nightly vs placebo; NSRP, nerve-sparing radical prostatectomy; SEP, Sexual Encounter Profile question
REINVENT: Levitra on-demand is as effective as nightly dosing in men with ED following bilateral NSRP1
All between-group comparisons were non-significant; IIEF-EF, International Index of Erectile Function, erectile function domain; NSRP, nerve-sparing radical prostatectomy.
Reference:
1. Montorsi F et al. Eur Urol 2008; 54: 924–31.
